Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: A randomized multicenter trial. Mehta SR et al. et al. , Lu B Clopidogrel 75 mg daily should be prescribed if prasugrel or ticagrelor are not suitable. , Yeh RW While clear evidence exists for the use of aspirin in maintaining graft patency, the role of dual-antiplatelet therapy in CABG patients is not as well established. Although coronary-artery bypass grafting (CABG) surgery has traditionally been the mainstay of treatment for patients with left main coronary artery (LMCA) disease, percutaneous coronary intervention (PCI) has undergone considerable evolution. Unfortunately, CE can cause the lack of endothelium, resulting in increased risk of thrombotic events. et al. Al Jaaly E (2015) Dual antiplatelet therapy after coronary artery bypass grafting: Do we have a consensus ntegr Cardiol, 2015, doi: 10.15761/JIC.1000126 Volume 1(4): 90-93 of P2Y1 893T and 1622G were 3.5 and 30.6%, respectively and these candidate genes were … , Cheng Z , Biocina B. Gershlick AH , Saunders N , Kerr AR et al. This work was supported by the Hamilton Health Sciences New Investigator Fund [NIF 17425 to S.G.]. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y 12 -receptor inhibitor is the recommended antithrombotic treatment for patients undergoing coronary bypass grafting (CABG) in the context of an acute coronary syndrome (ACS) (1, 2). 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As well, multiple SVG within patients were not independent but were treated as independent observations due to the reporting in the individual trials. Background In most situations, many patients undergoing coronary artery bypass graft (CABG) are on dual antiplatelet therapy (DAPT), which is also required after CABG. , Bueno H , Nicoloff DM. Terms of Use| , Salanti G Circulation 2012; 125: 2015–2026. Dual versus single antiplatelet therapy after coronary artery bypass graft surgery: An updated meta-analysis While DAPT has been associated with lower CV mortality in observational samples undergoing CABG, such findings were not replicated in RCTs. In recent guidelines, dual antiplatelet therapy (DAPT) with ASA and a P2Y 12 antagonist is recommended for all patients with ACS for at least 12 months. et al. Gaudino M coronary artery bypass grafting (CABG) in patients with diffuse coronary artery disease that could not be achieved complete revascularization by CABG or coron- ary stenting alone. , Oxman AD , Poston RS ASA: acetylsalicylic acid; CABG: coronary artery bypass grafting; CI: confidence interval; CrI: credible interval; GRADE: Grading of Recommendations Assessment, Development and Evaluation; MACE: major adverse cardiovascular events; NMA: network meta-analysis. The most common reasons for high risk of bias were issues with allocation concealment, participant and personnel blinding and outcome assessment blinding. Dual Antiplatelet Therapy after Coronary Artery Bypass Graft Surgery: A Review Hala Soomro 1, Salik Aleem , ... Coronary artery bypass graft surgery (CABG) is the gold standard treatment for relieving angina symptoms and reducing mortality among ischemic heart disease patients. , Parisi AF. We used the surface under the cumulative ranking curve to estimate the probability of each intervention being ranked first [22]. Aspirin monotherapy is currently recommended for patients with stable coronary artery disease after coronary artery bypass graft surgery to reduce saphenous vein graft failure.18 In patients who present with acute coronary syndromes, dual antiplatelet therapy is recommended to be resumed soon after coronary artery bypass graft surgery.2 51 52 However, there is a lack of evidence that dual … et al. Dual antiplatelet therapy after surgery should be tailored to the patient by balancing the safety and efficacy profile of the drug intervention against important patient outcomes. Currently, acetylsalicylic acid (ASA) monotherapy is the standard of care following CABG [5]. Emilie P. Belley-Cote: Conceptualization; Methodology; Writing—original draft; Writing—review & editing. 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